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Nutrition Information |
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Fructose Short-Circuits Glycolysis
First some terminology. Fructose ... a five carbon sugar that occurs naturally in fruit, does not cause as much insulin to be secreted as glucose and tastes sweeter than glucose. Glucose ... a six carbon sugar that is the breakdown product of glycogen(a polymer of glucose, multiple glucose units hooked together) that occurs naturally in potatoes and grains. Glycogen ... multiple units of glucose hooked together (a polymer). What is typically called "complex carbohydrate" today. Glycolysis ... derived from the Greek stem glyk- "sweet" and lysis meaning dissolution. The metabolic pathway for the initial utilization of glucose. Phosphofructokinase ... the enzyme that catalyzes the reaction of fructose 6-phosphate to fructose 1,6-biphosphate. You don't need to understand anything more about this reaction other than the fact that if fructose comes from a source other than the degradation of glucose, it blocks this step for glucose until all the non-glucose derived fructose has been metabolized. Glucose and Fructose Are Both Metabolized via Gylcolysis Both fructose and glucose are metabolized via glycolysis. Both end up at some point as three carbon fragments. In order for glucose to be broken down into three carbon fragments it must first be metabolized to a five carbon sugar, actually fructose. This is where the trouble starts, since fructose is already a five carbon sugar. The following analogy I hope will aid in explaining this. The analogy, however, is far from perfect. Whether we start out with separate glucose and fructose as in high fructose corn syrup or honey, or with fructose and glucose hooked together as in sucrose(common table sugar), makes no difference. As soon as sucrose hits the bloodstream, it is immediately broken down (hydrolyzed) to fructose and glucose. Freda Fructose gets married to Gary (Glucose) Sucrose. They live happily on Sugar Lane. Both work in muscle and liver cells where they are metabolized usually into fat and slow the immune system to a crawl. They get up early in the morning and both have to get on the Glycolysis Road to get to work. Gary (Glucose) is one carbon atom heavier than Freda Fructose and because of that, he cannot cross the river on one of the lighter and faster bridges on their way to work. Freda Fructose however, being lighter, has no problem crossing the faster bridge and making the short-cut to the Glycolysis Road. Gary Glucose, however, has to get on the road well above the short-cut, since he is too heavy to take the lighter bridge short-cut. The Phosphofructokinase Intersection As usual Freda Fructose gets to the Phosphofructokinase intersection well before Gary Glucose. By the time Gary Glucose gets to the intersection, the traffic directing policeman is once again allowing all the Freda Fructoses to make the turn onto Glycolysis Road while, all the Gary Glucoses can do is sit in traffic and wait. Once again, Gary, and all the other Glucoses on their way to work, must sit and wait for all the Freda Fructoses to get on Glycolysis Road before they can continue. LA Traffic Control Traffic control sees all these Glucoses sitting stuck in traffic, just like traffic backs up everyday in LA. It reacts by injecting a lot of green lights (insulin) into the pathway for the Glucoses to get to work. Finally, all the Fructoses pass and now because there are too many green lights, all the Glucoses pass quickly. All of the sudden there are no Glucoses to be found on the Glycolysis Road. All the cells along the way that used to be able to snag some Glucose can't because there isn't any. Whether it is the excessive insulin that is the cause of so many of the lifestyle diseases we see today or, all the backed up Gary Glucoses decide to cause their own damage to the arteries they are in, I don't know. It is however, clearly established that the ingestion of sucrose (fructose and glucose) is related to many of our lifestyle diseases today including the extensive damage to the vascular system that occurs with adult onset diabetes mellitus. I know, my damaged arteries are up on this site. Hypoglycemia Now you begin to feel lightheaded, dizzy and a bit disoriented. Traffic control has injected too many green lights and the concentration of glucose drops precipitously. The brain starts to complain because it no longer has enough glucose to function. If the blood sugar gets low enough, serious complications can occur. Fructose and Glucose Together The combination of fructose and glucose should be avoided as much as possible. When you eat your fruit, try to allow at least an hour or preferably two, before eating potatoes, whole grains or rice. Also avoid as much as you can sucrose, high fructose corn syrup, honey and maple syrup or, any sweetener that has as it main ingredients, fructose and glucose. Other Sweeteners Brown Rice Syrup Brown rice syrup is roughly about 45% maltose (two glucose units hooked together), 50% complex carbohydrates and 3% glucose. No glucose and fructose together but still sweet and I have known some people who can even get hypoglycemic from it. Barley Malt Syrup Made from whole barley it is about 65% Maltose and 30% complex carbohydrates. Fruit Concentrates These are usually combinations of glucose, fructose and sucrose and should be avoided. Maple Syrup Maple syrup is about 65% sucrose and should be avoided. Today's Health Tip: If you want sweet, you are safest with stevia. Next would be sweeteners derived from rice and barley. Sucrose, high fructose corn syrup, maple syrup and fruit juice concentrates should be avoided. Reference: Copyright John Mericle M.D. 2005 All Rights Reserved ************** One of our readers Wendy in the UK writes: Just to let you know that according to the website below that
takes you to Carol Bond Health Foods it is spelt Stevita. I
couldn't find it anywhere on the site and through asking
the chat section it was spelt differently. Thought you would
like to know so that you can let the other newsletter
recipients know. PS Really enjoy the newsletter. Find it very informing so thank
you. Gave up drinking milk last year after reading your article!
Feel much healthier as a result. To take Stevia for a test drive or purchase some online
follow the link below. I had luck just searching stevia
but you could also search the product "Stevita." DrMericle.com is devoted to achieving optimal health and peak performance through diet and lifestyle change. Dr. Mericle brings together a unique blend of formal training in organic chemistry and biochemistry, medical education, 29 marathons, 3 Hawaii Ironman competitions and a lot of practical real life experience.
Look For
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Take a look inside Lexington Herald Leader Vacation rentals to become a $100bn industry this year TravelDailyNews International Global Short Term Vacation Rentals Business Report GlobeNewswire Prominent Hawaii economist apologizes for obscene gesture during short-term rentals hearing Hawaii News Now Five Perfect Parisian Rentals for Your Olympics Vacation Elite Traveler How to Avoid Paying Vacation Rental Fees The New York Times The Rise Of Vacation Rentals: How Technology And Preferences Are Shaping The Market Travel And Tour World San Diego’s short-term rental rules a year later: Is the city cracking down on scofflaws? The San Diego Union-Tribune How B2B startup Inhaven is reworking vacation rentals Digital Commerce 360 Emerald Coast by Owner (ECBYO) Unveils New Website With Expanded Coverage and Enhanced Features StreetInsider.com Prominent Hawaii economist apologizes for obscene gesture during short-term rentals hearing Hawaii News Now Vacation Home Openings This Time of Year on Oregon Coast? Yes, Even in Pacific City Oregon Coast Beach Connection DeSantis vetoes short-term vacation rental bill Florida Phoenix Gov. DeSantis vetoes vacation rental bill News 13 Orlando Florida Gov. DeSantis vetoes vacation rental bill that gave state more authority Tallahassee Democrat AG Ashley Moody Warns Floridians About Vacation Rental Scams In Summer Scams Series Tampa Free Press Maui County’s Move Against Vacation Rentals Likely To Bog Down In Court Honolulu Civil Beat Florida Governor Vetoes Bill Regulating Vacation Rentals coastalbreezenews.com A new vacation rental problem travelers need to know about The Seattle Times Global Vacation Rental Market to Hit $100 Billion This Year eTurboNews | eTN Maui Council Budgets $300,000 To Study Impacts Of Eliminating 7,000 Vacation Rentals Honolulu Civil Beat Vacation Rentals Florida Trend Tybee officially passes ban on vacation rentals. Here's what that means for the island WJCL News Savannah How are Bayfield vacation rentals impacting housing availability, expenses? The Durango Herald FL lawmakers pass state regulations on short-term vacation rentals; how will it play out? Florida Phoenix Buckingham Vacation Rentals Visit Lake Tahoe Counties differ in approach to regulating vacation rentals Hawaii Tribune-Herald Vacation Rentals: How to Shrink Your Carbon Footprint The New York Times Vacation Rental Prices Come Down From Pandemic High The Vineyard Gazette - Martha's Vineyard News Galveston Central Appraisal district begins treating vacation rentals as businesses Galveston County Daily News Florida’s Vacation Rental Bill awaits Gov. Ron DeSantis' review. St. Augustine Record Lee Cataluna: Phasing Out 7,000 Vacation Rentals On Maui Would Be A Sea Change - Honolulu Civil Beat Lee Cataluna: Phasing Out 7,000 Vacation Rentals On Maui Would Be A Sea Change Honolulu Civil Beat Editorial: New limits on Marin vacation rentals make sense Marin Independent Journal Hawaii lawmakers take aim at vacation rentals after Lahaina wildfire amplifies Maui housing crisis The Associated Press Governor signs measure giving counties authority to convert vacation rentals into housing Hawaii News Now Short-Term Dwelling and Vacation Rental Licensing Boulder County (.gov) Maui Mayor Richard Bissen announces bill to phase out vacation rentals in apartment districts Maui Now Vacation rentals, presidential politics in Florida and the financial forecast for abortion amendment WUSF Vrbo's Top Vacation Rentals for 2024 Include Homes in Cabo, the Caribbean, and Sedona Travel + Leisure Hawaii governor pledges to sign vacation rental regulation bill Courthouse News Service A Statewide Ban On Vacation Rentals? The Idea Is Gaining Steam After The Maui Fires Honolulu Civil Beat Reconnect With Nature When You Stay At These Charming Rentals In Georgia Only In Your State Vacation rental bill divided lawmakers. Now it's drawing calls for DeSantis to veto it Tallahassee Democrat Short-term vacation rental bill barely passes Florida House Florida Phoenix Letter: Vacation rental vs. low to middle-class housing The News Guard |
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